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2018.08.30 12:17

Buy Nolvadex Astrazeneca

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BUY NOLVADEX ONLINE

Generic Tamoxifen

Nolvadex is a trade mark for generic Tamoxifen, a nonsteroidal anti-estrogens medicine, which has an anti-tumor effect. Tamoxifen inhibits autogenic estrogen receptors and it slows the progression of a tumor, which is stimulated by estrogen. Thus, Generic Tamoxifen is used to treat diseases such as mammary cancer (especially in menopausal women), mammary ductal carcinoma, tumors which are sensitive to estrogen, endometrial cancer.

Before you start using the medication, you should consult your personal doctor and undergo a full medical examination (for excluding pregnancy). Do not use the medication if you are hypersensitive to any component of Nolvadex . if you are pregnant or breast-feeding. Use with caution in patients with thrombocytopenia, leukopenia, hypercalcemia, cataract or dysopia, deep vein thrombosis, liver failure. Do not use the medication together with Clomid other medicines that contain hormones, especially estrogen.

Generic Tamoxifen is manufactured by AstraZeneca

AstraZeneca is a worldwide pharmaceutical and biologics corporation. AstraZeneca manufactures and sells medicine for treatment of diseases in different fields. The company is widely known for its medications for oncology treatment. Nolvadex is one of the most popular medicines in this field. Nolvadex is made of high quality generic Tamoxifen and it is the best choice for women with breast cancer. However, it is ineffective in treatment of patients with metastatic.

It is important to know that women, who took Tamoxifen, should use non-hormonal methods of contraception. Do not use oral contraceptives: it is inefficient and unacceptable.

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Our company purchases medicine from its manufacturers, so when you buy Nolvadex online in our pharmacy, you protect yourself from defective products and fakes. In our online pharmacy you can buy Tamoxifen at best price, so if you order Tamoxifen right now, you will save your money. Buy Nolvadex now and win the battle against cancer!



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Nolvadex- D is manufactured in the U.K. by Astra Zeneca Limited. Nolvadex- D is not a steroid it is an anti -estrogen . it is a nonsteroidal agent which demonstrates potent anti-estrogenic properties. These antiestrogenic effects are due to its ability to compete with estrogen for binding sites in target tissues such as in the breast. Medically, the affects of this drug make it very usefull in breast cancer patients. Male bodybuilders however find this drug very affective in combating Gynocomastia (female breast tissue developement) Gynocomastia is caused by acces Estrogen in the male body. In the steroid user, this happens when anabolic steroids aromatize into Estrogens. This is not as odd as you may think. structurally these hormones are very similar. So with Nolvadex competing for any occupying estrogen receptors, the build up of tissue is greatly reduced and often avoided.



Nolvadex is used for treating breast cancer that has spread to other sites in the body. It is also used along with other medicines to treat other types of breast cancer. It is used in women who are at high risk for breast cancer and in women with DCIS (after surgery and radiation) to decrease the risk of developing breast cancer. Nolvadex is an antiestrogen. It works by blocking the effect of estrogen on certain tumors. This may prevent the growth of tumors that are activated by estrogen.

Use Nolvadex as directed by your doctor.

Nolvadex may be taken by mouth with or without food.

Take Nolvadex with water or another nonalcoholic liquid.

Swallow this medication whole. Do not break, crush, or chew before swallowing.

Continue to take Nolvadex even if you feel well. Do not miss any dose. Taking Nolvadex at the same time each day will help you to remember to take it.

If you miss a dose of Nolvadex, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Store Nolvadex between 68 and 77 degrees F (20 and 25 degrees C) in a tightly closed, light-resistant container. Store away from moisture, heat, and light. Do not store in the bathroom. Do not take tablets after the expiration date printed on the label. Keep Nolvadex out of the reach of children and away from pets.

Active Ingredient: Tamoxifen.



Arimidex (Anastrozole)

Arimidex is a powerful anti-estrogen medication more aptly labeled an aromatase inhibitor (AI) originally developed to treat breast cancer. As is common with many AIs and anti-estrogen medications designed for this purpose Arimidex has found a welcomed home in the world of performance enhancing based on the same attributes designed in its original intent. Comprised of the active drug Anastrozole, the original trade name given was by its creator AstraZeneca and most forms regardless of manufacture will follow suit with either the original trade name of the actual drug name itself.

Arimidex performs by actively blocking the aromatase enzyme; this is important for steroid users as the aromatase process is what is responsible for many of the negative side-effects commonly associated with anabolic steroid use. As many anabolic steroids convert to estrogen such side-effects as Gynecomastia and excess water retention can become a problem to name a few but with supplemental Arimidex such problems can largely be reduced and often eliminated altogether. Through supplemental Arimidex use we actively block the estrogen conversion and reduce the total amount of estrogen in the body thereby preventing what isnt there from binding to the receptors of the body.

While Arimidex can be used while on cycle as well as during post cycle therapy (PCT) most will find its use is best served while on cycle and the using of SERMs to be the best bet during a PCT. However, for on cycle purposes AIs such as Arimidex will prove to be far more beneficial and effective; more so than SERMs although they can be used here as well. While an AI such as Arimidex will actually reduce estrogen a SERM such as Nolvadex or Clomid will not; these SERMs will only block the estrogen from binding and they will not block all of it and will not reduce. However, as Arimidex will reduce total levels too much will do so to a degree that will actually hinder the athletes progression as some estrogen is needed for tissue gains and more importantly a well-functioning body.

The manner by-which Arimidex reduces estrogen is really the main reason why its not a preferred PCT medication. Yes, it will increase testosterone levels during the PCT period, the entire purpose of the PCT process to begin with but the estrogen reduction is too much for this purpose and SERMs will prove to be a better choice to meet this end. A solid plan for most to follow is a small dosing of Arimidex while on cycle; generally 0.5mg every other day will get the job done, although some will need to go as high as 1mg every other day in order to prevent side-effects from anabolic steroid use. As 1mg will prove to be our general max dose those in the competitive bodybuilding world will often supplement with 1mg every single day shortly before competition. Short periods of high dosing will provide a physique a much harder and dryer look but in this case such dosing will generally only last 7-14 days in total duration as some estrogen is needed in the body for the long haul. Once the cycle of anabolic steroids is complete and the PCT period begins dropping all Arimidex and anabolic steroids and beginning therapy with SERMs such as Nolvadex and Clomid will prove to be optimal as they will increase natural testosterone production while allowing enough estrogen in the body to perform the designated tasks.



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Full Description

AstraZeneca PLC (AstraZeneca), incorporated on June 17, 1992, is a global biopharmaceutical company. AstraZeneca discovers, develops and commercializes prescription medicines for six areas of healthcare: Cardiovascular, Gastrointestinal, Infection, Neuroscience, Oncology, and Respiratory and Inflammation. It has a range of medicines that includes treatments for illnesses, such as its antibiotic, Merrem/Meronem and Losec/Prilosec for acid related diseases. AstraZeneca’s products include Crestor, Atacand,Seloken/Toprol-XL, Plendil, Onglyza, Zestril, Symbicort and Zoladex. The Company owns and operates a range of research and development (R&D), production and marketing facilities worldwide. AstraZeneca operates in over 100 countries, including China, Mexico, Brazil and Russia. On August 31, 2011, the Company completed the sale of the Astra Tech business to DENTSPLY International Inc. On June 19, 2012, the Company acquired Ardea Biosciences Inc (Ardea), a biotechnology company in San Diego, California. In July 2012, the Company acquired a portfolio of neuroscience assets from Link Medicine Corporation. In August 2012, Alliance Pharma plc’s wholly owned subsidiary, Alliance Pharmaceuticals Limited, acquired the antimalarial brands Paludrine, Avloclor and Savarine from AstraZeneca UK Limited. In August 2012, the Company and Bristol-Myers Squibb Company announced the acquisition of Amylin Pharmaceuticals, Inc. by Bristol-Myers Squibb Company. In June 2013, the Company acquired Pearl Therapeutics. In July 2013, AstraZeneca PLC has sold its toxicological laboratory in Gartuna to Acturum. On July 18, 2013, the Company acquired Omthera Pharmaceuticals. In October 2013, AstraZeneca Plc completed its acquisition of Amplimmune. In October 2013, AstraZeneca PLC announced that MedImmune acquired Spirogen. In January 2014, Probiodrug AG transferred its experimental cyclin-dependent kinase 9 (CDK9) inhibitor program to AstraZeneca. In February 2014, Bristol-Myers Squibb Co completed the sale of its global diabetes business to AstraZeneca.

Cardiovascular

The Company’s marketed products include Crestor (rosuvastatin calcium), Atacand2 (candesartan cilexetil), Seloken/Toprol-XL (metoprolol succinate), Tenormin (atenolol), Plendil (felodipine), Zestril3 (lisinopril dihydrate), Brilinta/Brilique (ticagrelor), and Axanum, (acetylsalicylic acid (ASA). Crestor1 is a statin used for the treatment of dyslipidaemia and hypercholesterolemia. In some markets, it is also indicated to slow the progression of atherosclerosis and to reduce the risk of first cardiovascular (CV) events. Atacand2 is an angiotensin II antagonist used for the 1st line treatment of hypertension and symptomatic heart failure. Seloken/Toprol-XL is a beta-blocker once-daily tablet used for 24-hour control of hypertension and for use in heart failure and angina.

Tenormin is a cardioselective beta-blocker used for hypertension, angina pectoris and other CV disorders. Plendil is a calcium antagonist used for the treatment of hypertension and angina. Zestril3 is an angiotensin-converting enzyme inhibitor used for the treatment of a wide range of CV diseases, including hypertension. Brilinta/Brilique is an oral antiplatelet for the treatment of acute coronary syndromes (ACS). Axanum is a fixed dose combination indicated for prevention of CV events in high-risk CV patients in need of daily low-dose ASA treatment and who are at risk of gastric ulcers.

The Company’s marketed products for diabetes include Komboglyze ((saxagliptin and metformin HCl), Kombiglyze XR (saxagliptin and metformin XR) and Onglyza (saxagliptin). Komboglyze is an immediate release fixed dose combination indicated as an adjunct to diet and exercise to improve glycaemic control in adult patients with Type 2 diabetes mellitus inadequately controlled on their maximally tolerated dose of metformin alone or those already being treated with the combination of saxagliptin and metformin as separate tablets. Kombiglyze XR is an extended release fixed dose combination indicated as an adjunct to diet and exercise to improve glycaemic control in adults with Type 2 diabetes mellitus when treatment with both saxagliptin and metformin is appropriate. Onglyza is a DPP-IV inhibitor used for the treatment of Type 2 diabetes.

Gastrointestinal

AstraZeneca’s marketed products include Nexium (esomeprazole), Losec/Prilosec (omeprazole) and Entocort (budesonide). Nexium is a proton pump inhibitor (PPI) used for the treatment of acid-related diseases to offer clinical improvements over other PPIs and other treatments. Losec/Prilosec is used for the short-term and long-term treatment of acid-related diseases. Entocort is a corticosteroid used for the treatment of inflammatory bowel disease. Nexium is marketed in approximately 120 countries and is available in oral (tablet/capsules and oral suspension) and intravenous (i.v.) dosage forms for the treatment of acid-related diseases.

Infection

The Company’s marketed products include Merrem/Meronem (meropenem), Cubicin (daptomycin) and FluMist/Fluenz (influenza vaccine live, intranasal). Merrem/Meronem is a carbapenem anti-bacterial used for the treatment of kamagra serious infections in hospitalised patients. Cubicin is a cyclic lipopeptide anti-bacterial used for the treatment of serious infections in hospitalised patients. FluMist/Fluenz is an intranasal live, attenuated, trivalent influenza vaccine.

Neuroscience

AstraZeneca’s marketed products include Seroquel IR (quetiapine fumarate), Seroquel XR (an extended release formulation of quetiapine fumarate), Zomig (zolmitriptan), Diprivan (propofol), Vimovo (naproxen/esomeprazole magnesium), Naropin (ropivacaine), Xylocaine (lidocaine) and EMLA (lidocaine and prilocaine). Seroquel IR is an atypical anti-psychotic drug used for the treatment of schizophrenia and bipolar disorder (mania, depression and maintenance). Seroquel XR is used for the treatment of schizophrenia, bipolar disorder, MDD and in some territories for generalised anxiety disorder (GAD).

Zomig is used for the treatment of migraines with or without aura and Zomig Nasal Spray is indicated for the acute zithromax treatment of cluster. Diprivan is an intravenous general anaesthetic used in the induction and maintenance of general anaesthesia, for use in intensive care sedation and conscious sedation for surgical as well as diagnostic procedures. Vimovo is a fixed-dose combination of enteric-coated naproxen (an NSAID) with the gastroprotection of immediate release esomeprazole (a proton pump inhibitor) for the relief of signs and symptoms of osteoarthritis, rheumatoid arthritis and ankylosing spondylitis, and to decrease the developing of gastric ulcers in patients at risk of developing NSAID-associated gastric ulcers. Naropin is used as a long-acting local anaesthetic, for surgical anaesthesia and acute pain management. Xylocaine is a used short-acting local anaesthetic. EMLA is used as a local anaesthetic for topical application.

Oncology

AstraZeneca’s marketed products include Arimidex (anastrozole), Zoladex (goserelin acetate implant), Casodex (bicalutamide), Iressa (gefitinib), Faslodex (fulvestrant), Nolvadex (tamoxifen citrate) and Caprelsa (vandetanib). Arimidex is an aromatase inhibitor used for the treatment of early breast cancer. Zoladex, in one- and three-month depots, is a luteinising hormone-releasing hormone agonist used for the treatment of prostate cancer, breast cancer and certain benign gynaecological disorders. Casodex is an anti-androgen therapy used for the treatment of prostate cancer.



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AstraZeneca steps up push into cancer immunotherapy

By Ben Hirschler

LONDON (Reuters) - AstraZeneca is accelerating its push into cancer immunotherapy, with plans to test a key experimental drug in new tumor types.

The company is seen as No. 4 in a race to develop the first drug in a new class that fights cancer by unleashing the body's immune system, behind rivals Roche, Merck & Co and Bristol-Myers Squibb.

But its MEDI4736 medicine is still viewed as a highly promising agent, both on its own and in combination with other treatments.

AstraZeneca said on Thursday it would launch a pivotal clinical trial program with MEDI4736 in head and neck cancer this year, in addition to ongoing tests in lung cancer, and was also looking at expanding tests into other cancer types.

"There is the potential we would announce an additional tumor type beyond head and neck and non-small cell lung cancer by the end of this year," head of medicines development Briggs Morrison told analysts in a post-results conference call.

MEDI4736 is part of a closely watched class of drugs known as anti-PD-L1 therapies, which block a tumor's ability to evade the immune system's defenses.

AstraZeneca said it would present further data looking at MEDI4736 in lung cancer, as well as early results for head and neck cancer, in September at the annual meeting of the European Society for Medical Oncology.

Analysts said the decision to study MEDI4736 in head and neck cancer made sense, given encouraging results with a similar Merck drug for the condition reported in June.

The commercial promise of MEDI4736 was flagged by AstraZeneca during its recent $118 billion takeover battle with Pfizer, when it argued that the drug - used on its own and in combination with other therapies - could potentially generate annual sales of $6.5 billion.

In recent years, the British drugmaker has become best known for its cholesterol drug Crestor and its ulcer and heartburn pill Nexium. But it has a long history in oncology, having broken new ground decades ago in developing tamoxifen and other hormonal therapies. It also produced one of the first "targeted" cancer drugs, Iressa.

AstraZeneca earlier raised its sales and earnings forecasts for 2014 after second-quarter sales and earnings both beat expectations, helped by several one-off factors.

(Editing by David Holmes)

Pharmaceuticals & Drug Trials Health AstraZeneca cancer immunotherapy lung cancer head and neck cancer





≥99%

PubChem Substance ID 24900307

Description

Live Chat and Frequently Asked Questions are available for this Product.

Tamoxifen is a selective estrogen response modifier (SERM), protein kinase C inhibitor and anti-angiogenetic factor. Tamoxifen is a prodrug that is metabolized to active metabolites 4-hydroxytamoxifen (4-OHT) and endoxifen by cytochrome P450 isoforms CYP2D6 and CYP3A4. In breast cancer, the gene repressor activity of tamoxifen against ERBB2 is dependent upon PAX2. Blocks estradiol-stimulated VEGF production in breast tumor cells.

1, 5 g in glass bottle

Tamoxifen is soluble in chloroform at 50 mg/ml and yields a clear, colorless to faint yellow solution. It is also soluble in methanol, ethanol, 2-propanol and propylene glycol. Stock solutions of tamoxifen can also be prepared in DMSO at 10 mM. However, it is practically insoluble in water (solubility is <0.01%, 20° C). Solutions are sensitive to UV light, and DMSO solutions are stable when stored at -20° C in the dark.

Tamoxifen has been used to facilitate the recombination of ect2 flox allele in mouse organs 91. It has also been used to study its effect on lipopolysaccharide (LPS)-induced microglial activation 92.

Protein kinase C inhibitor. Induces apoptosis in human malignant glioma cell lines. Tamoxifen and its metabolite 4-hydroxytamoxifen are selective estrogen response modifiers (SERMs) that act as estrogen antagonists in mammary gland. Blocks estradiol-stimulated VEGF production in breast tumor cells.

This compound is also offered as part of Sigma′s Library of Pharmacologically Active Compounds (LOPAC ®, 1280 ), a biologically annotated collection of high-quality, ready-to-screen compounds. Click here to learn more.

This compound was developed by AstraZeneca. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
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